by Sam Najmabadi, MD
Noninvasive chromosome screening (NICS) is a method based on sequencing the genomic DNA secreted into the culture medium from the human blastocyst. We are using this new method as it is highly accurate and far less invasive than Preimplantation genetic screening (PGS).
PGS has been widely used to select in vitro-fertilized embryos free of chromosomal abnormalities and to improve the clinical outcome of in vitro fertilization (IVF). The main disadvantage of PGS is that it requires a biopsy of the preimplantation human embryo, which can limit the clinical applicability of PGS due to the invasiveness and complexity of the process.
Patients that are interested in NICS will first come in for a consultation with Dr. José Luis Rivas. Once the patient has started IVF, the ICSI technique is used to fertilize an egg with sperm. We will grow the embryo to blastocyst, then once it reaches the blastocyst stage we collect the liquid from the dish the embryo has been cultured in and we test the liquid. Chromosome screening can be done with this liquid instead of biopsying the embryo. Previously biopsying an embryo was the only option, but this requires cutting cells out of the embryo and potentially decreasing the embryo quality. This invasive approach can have negative influences on development of the embryo.
Previously biopsying an embryo was the only option. But when you biopsy an embryo you have to cut cells out of the embryo and potentially decrease the embryo quality, once the quality of an embryo has been decreased it can have negative influences on development of the embryo and possibly in the womb.
Please give our offices a call today if you would like to set up a consultation for this procedure or have any additional questions.