The World Health Organization estimates that diabetes will be the fourth most prevalent disease by 2050.

Developing a new therapy for diabetes is a challenge for researchers and clinicians in field.

Many medications are being used for treatment of diabetes however with no conclusive and effective results therefore alternative therapies are required.

Stem cell therapy is a promising tool for diabetes therapy, and it has involved embryonic stem cells, adult stem cells, and pluripotent stem cells. In this review, we focus on adult stem cells, especial human bone marrow stem cells (BM) for diabetes therapy, its history, and current development.

We discuss prospects for future diabetes therapy such as induced pluripotent stem cells which have popularity in stem cell research area.

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